Ibrahim Youssef

Twelve years of teaching and research experiences, including corporate and academic research in United states of America, Egypt, and Saudi Arabia. PhD. in Polymer Chemistry from Joint supervision scholarship between Biomedical Engineering Department (BME), University of Michigan, Ann Arbor, USA which is one of most distinguished Biomedical Science and Engineering department in the world As a joint department, Michigan BME combines the strengths of two schools that are among the very best in their fields - the U-M College of Engineering and the Michigan Medical School. It’s one of just two universities in the country with this broad level of excellence (#5 Best Engineering school) and Chemistry Department, School of Science, Mansoura University, Egypt (#17 Best University in Africa and #4 in Egypt 2017). BME provides leadership in education, training and cutting-edge research by translating science and engineering to solve important challenges in medicine and life sciences to the benefit of humanity. My work is well recognized and I have been invited to present my ideas and results in several conferences and well-known institutes in USA, UK, United Arab Emirates, Turkey, Egypt, and Saudi Arabia. I have published four research papers in highly recognized international journals with high impact factors. Currently in the process of publishing, three more research papers. Work presented in seventeen international conferences and symposia, and invited by different institutes to present novel ideas. Research work recognized by several organizations and honored by many awards. My research experience extended to supervision and monitoring of three postgraduate students, one doctoral and two masters. Unique chemistry graduates who gained (during PhD work) a massive experience in pharmaceutical analysis, biological techniques and Drug delivery therapeutics methodologies concomitantly with work as teaching assistant for undergraduate students. During my PhD work, I improved my Chemistry background from routine application of synthesis methodologies to deep and massive expertise in Cell and Cancer Cell Biology, Biological Techniques, Fabrication, Formulation, Biocompatibility studies and drug delivery of Chemotherapeutics agents into a specific location in the body using targeting moieties. Moreover, my research made me one of the top field scientists in Polymer Chemistry with biomedical applications. The focus of my research is to improve the reliability and sensitivity of the delivery vehicles used and to apply it for Cancer therapeutics. Overall, my work not only helps in cost savings, most importantly it helps improve the quality of life through various applications. I joined Prof ElSayed’s research group (Cellular Engineering & Nano-Therapeutics Laboratory (CENT LAB)) as a Visiting Scholar with the financial support of an individual scholarship from the Egyptian Ministry of Higher Education for two consecutive years (April 2013 to April 2015). I secured this scholarship through a competitive process that took into account my distinctive academic record during my undergraduate and MS studies at Mansoura University, Egypt. My training and prior research experience is the field of synthetic organic chemistry, which was quite different from the scope of ElSayed’s research program. However, this did not deter me from pursuing my research as part of the group. For the first 4 months, I spent a great deal of time reviewing the literature focusing on the development new biomaterials for drug delivery and preclinical assessment of investigational therapies. Our regular discussion with the research group and my PI revealed a steady improvement in my understanding of the field and appreciation of the complexities in developing new targeted therapies. I worked very closely with a Dr. Yasemin Durmaz who was a postdoctoral fellow in CENTLAB group and currently an Assistant Professor at Istanbul Medipol University to learn the design and synthesis of new polymers using sophisticated techniques. I proved to be a fast learner and I was able to acquire many of the needed skills over a short period of time. My performance was impacted and supported the competitive renewal of my scholarship for a second year. My research focused on the design and synthesis of novel polymeric micelles that can be used to deliver chemotherapeutic agents to metastatic cancer lesions in bone. I was able to synthesize a series of multi-block copolymers, formulate the desired micelles, encapsulate different types of guest molecules, and monitor the release of the loaded cargo in different solution conditions. I also expanded my training to include aseptic cell culture techniques and I successfully established and maintained 2 prostate cancer cell lines that were used in subsequent studies. I quantified the activity of drug-loaded micelles against these cell lines and his results shows successful and efficient intracellular delivery of the loaded drug into prostate cancer cells. In fact, drug-loaded micelles proved to be efficient in killing more cancer cells compared to the free drug at equal concentrations. My results on this first phase of the project are reported in ~12 peer-reviewed conference proceedings listed in my resume. I was a key contributor to a research manuscript that published in an excellent journal in the field of Drug delivery with high impact factor 4.44 (Omer Aydin, Ibrahim Youssef *, Yasemin Yuksel Durmaz, Gopinath Tiruchinapally and Mohamed E.H. ElSayed, “Formulation of acid-sensitive micelles for delivery of cabazitaxel into prostate cancer cells”, Journal of Molecular Pharmaceutics 2016, 13 (4), 1413-1429) and the second paper comes out from this great project is in the final makeup stage to be submitted. We capitalized on these great results and explored the possibility of incorporating bone-targeting peptides to our micelles. My contributed to the synthesis of these bone-targeting micelles. Furthermore, I carried our detailed studies of micelles binding to different forms of bine (e.g. bone powder, chips, discs) and my results provide proof-of-concept that targeting bone surface using our micelles is feasible.





Research areas

Delivery chemotherapeutic agent into Metastatic prostate cancer


Mansoura University