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[New] Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance.

Research paper by Ewelina E Piktel, Izabela I Prokop, Urszula U Wnorowska, Grzegorz G Król, Mateusz M Cieśluk, Katarzyna K Niemirowicz, Paul B PB Savage, Robert R Bucki

Indexed on: 19 May '18

Published on: 19 May '18 in Oncotarget

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[New] 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.

Research paper by J Y JY Akakpo, A A Ramachandran, S E SE Kandel, H M HM Ni, S C SC Kumer, B H BH Rumack, H H Jaeschke

Indexed on: 10 May '18

Published on: 10 May '18 in Human & experimental toxicology

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[New] Ethical implications of medical crowdfunding: the case of Charlie Gard.

Research paper by Gabrielle G Dressler, Sarah A SA Kelly

Indexed on: 08 May '18

Published on: 08 May '18 in Journal of medical ethics

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[New] Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes.

Research paper by Patrick P Orlando, Sonia S Silvestri, Roberta R Galeazzi, Roberto R Antonicelli, Fabio F Marcheggiani, Ilenia I Cirilli, Tiziana T Bacchetti, Luca L Tiano

Indexed on: 08 May '18

Published on: 08 May '18 in Redox report : communications in free radical research

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[New] ONC201 kills breast cancer cells in vitro by targeting mitochondria.

Research paper by Yoshimi Endo YE Greer, Natalie N Porat-Shliom, Kunio K Nagashima, Christina C Stuelten, Dan D Crooks, Vishal N VN Koparde, Samuel F SF Gilbert, Celia C Islam, Ashley A Ubaldini, Yun Y Ji, Luca L Gattinoni, Ferri F Soheilian, Xiantao X Wang, Markus M Hafner, Jyoti J Shetty, et al.

Indexed on: 03 May '18

Published on: 03 May '18 in Oncotarget

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[New] Endonuclease G promotes mitochondrial genome cleavage and replication.

Research paper by Rahel Stefanie RS Wiehe, Boris B Gole, Laurent L Chatre, Paul P Walther, Enrico E Calzia, Miria M Ricchetti, Lisa L Wiesmüller

Indexed on: 03 May '18

Published on: 03 May '18 in Oncotarget

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[New] Right Brain: Withholding treatment from a child with an epileptic encephalomyopathy.

Research paper by Aaron A Rothstein, Ariane A Lewis

Indexed on: 02 May '18

Published on: 02 May '18 in Neurology

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[New] Inositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients.

Research paper by Matteo M Suman, Jenny A JA Sharpe, Robert B RB Bentham, Vassilios N VN Kotiadis, Michela M Menegollo, Viviana V Pignataro, Jordi J Molgó, Francesco F Muntoni, Michael R MR Duchen, Elena E Pegoraro, Gyorgy G Szabadkai

Indexed on: 28 Apr '18

Published on: 28 Apr '18 in Human molecular genetics

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[New] Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells.

Research paper by Jing-Jing JJ Mou, Jin J Peng, Ying-Ying YY Shi, Na N Li, You Y Wang, Yuan Y Ke, Yun-Feng YF Zhou, Fu-Xiang FX Zhou

Indexed on: 24 Apr '18

Published on: 24 Apr '18 in Biomedicine & Pharmacotherapy

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[New] Intracellular calcium is a rheostat for the STING signaling pathway.

Research paper by Dohyeong D Kwon, Hiromi H Sesaki, Suk-Jo SJ Kang

Indexed on: 21 Apr '18

Published on: 21 Apr '18 in Biochemical and Biophysical Research Communications

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[New] Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

Research paper by Oswaldo A OA Lozoya, Inmaculada I Martinez-Reyes, Tianyuan T Wang, Dagoberto D Grenet, Pierre P Bushel, Jianying J Li, Navdeep N Chandel, Richard P RP Woychik, Janine H JH Santos

Indexed on: 19 Apr '18

Published on: 19 Apr '18 in PLoS biology

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[New] Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency.

Research paper by Aida A Rodríguez-Nuevo, Angels A Díaz-Ramos, Eduard E Noguera, Francisco F Díaz-Sáez, Xavier X Duran, Juan Pablo JP Muñoz, Montserrat M Romero, Natàlia N Plana, David D Sebastián, Caterina C Tezze, Vanina V Romanello, Francesc F Ribas, Jordi J Seco, Evarist E Planet, Susan R SR Doctrow, et al.

Indexed on: 11 Apr '18

Published on: 11 Apr '18 in The EMBO Journal

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[New] Characterization of the novel mitochondrial genome replication factor MiRF172 in Trypanosoma brucei .

Research paper by Simona S Amodeo, Martin M Jakob, Torsten T Ochsenreiter

Indexed on: 08 Apr '18

Published on: 08 Apr '18 in Journal of cell science

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[New] Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer.

Research paper by Xiacheng X Sun, Lei L Zhan, Yibing Y Chen, Gang G Wang, Linjie L He, Qian Q Wang, Feng F Zhou, Fang F Yang, Jin J Wu, Yousheng Y Wu, Jinliang J Xing, Xianli X He, Qichao Q Huang

Indexed on: 04 Apr '18

Published on: 04 Apr '18 in Signal Transduction and Targeted Therapy

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[New] Retrospective natural history of thymidine kinase 2 deficiency.

Research paper by Caterina C Garone, Robert W RW Taylor, Andrés A Nascimento, Joanna J Poulton, Carl C Fratter, Cristina C Domínguez-González, Julie C JC Evans, Mariana M Loos, Pirjo P Isohanni, Anu A Suomalainen, Dipak D Ram, M Imelda MI Hughes, Robert R McFarland, Emanuele E Barca, Carlos C Lopez Gomez, et al.

Indexed on: 01 Apr '18

Published on: 01 Apr '18 in Journal of medical genetics

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[New] The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.

Research paper by Fenna F Hensen, Amandine A Moretton, Selma S van Esveld, Géraldine G Farge, Johannes N JN Spelbrink

Indexed on: 31 Mar '18

Published on: 31 Mar '18 in Scientific Reports

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[New] The presence of rNTPs decreases the speed of mitochondrial DNA replication.

Research paper by Josefin M E JME Forslund, Annika A Pfeiffer, Gorazd G Stojkovič, Paulina H PH Wanrooij, Sjoerd S Wanrooij

Indexed on: 31 Mar '18

Published on: 31 Mar '18 in PLoS genetics

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[New] High-throughput terrestrial biodiversity assessments: mitochondrial metabarcoding, metagenomics or metatranscriptomics?

Research paper by John-James JJ Wilson, Guo-Jie GJ Brandon-Mong, Han-Ming HM Gan, Kong-Wah KW Sing

Indexed on: 30 Mar '18

Published on: 30 Mar '18 in Mitochondrial DNA. Part A. DNA mapping, sequencing, and analysis

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[New] Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine

Research paper by Ana Santos-Llamas, Maria J. Monte, Jose J. G. Marin, Maria J. Perez

Indexed on: 29 Mar '18

Published on: 28 Mar '18 in Archives of Toxicology

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[New] Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells

Research paper by Miriam Pons, Claudia M. Reichardt, Dorle Hennig, Abinaya Nathan, Nicole Kiweler, Carol Stocking, Christian Wichmann, Markus Christmann, Falk Butter, Sigrid Reichardt, Günter Schneider, Thorsten Heinzel, Christoph Englert, Jörg Hartkamp, Oliver H. Krämer, et al.

Indexed on: 28 Mar '18

Published on: 27 Mar '18 in Archives of Toxicology

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[New] Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Research paper by Amara A Maryam, Tahir T Mehmood, Qiulong Q Yan, Yongming Y Li, Muhammad M Khan, Tonghui T Ma

Indexed on: 27 Mar '18

Published on: 27 Mar '18 in Oxidative medicine and cellular longevity

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[New] Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

Research paper by Stanka S Matic, Min M Jiang, Thomas J TJ Nicholls, Jay P JP Uhler, Caren C Dirksen-Schwanenland, Paola Loguercio PL Polosa, Marie-Lune ML Simard, Xinping X Li, Ilian I Atanassov, Oliver O Rackham, Aleksandra A Filipovska, James B JB Stewart, Maria M Falkenberg, Nils-Göran NG Larsson, Dusanka D Milenkovic

Indexed on: 25 Mar '18

Published on: 25 Mar '18 in Nature communications

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[New] The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway.

Research paper by Qiongyuan Q Hu, Jianan J Ren, Guanwei G Li, Jie J Wu, Xiuwen X Wu, Gefei G Wang, Guosheng G Gu, Huajian H Ren, Zhiwu Z Hong, Jieshou J Li

Indexed on: 16 Mar '18

Published on: 16 Mar '18 in Cell Death & Disease

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[New] Ciprofloxacin triggers the apoptosis of human triple-negative breast cancer MDA-MB-231 cells via the p53/Bax/Bcl-2 signaling pathway.

Research paper by Artur A Beberok, Dorota D Wrześniok, Jakub J Rok, Zuzanna Z Rzepka, Michalina M Respondek, Ewa E Buszman

Indexed on: 14 Mar '18

Published on: 14 Mar '18 in International journal of oncology

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[New] Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

Research paper by Veronika V Boczonadi, Martin S MS King, Anthony C AC Smith, Monika M Olahova, Boglarka B Bansagi, Andreas A Roos, Filmon F Eyassu, Christoph C Borchers, Venkateswaran V Ramesh, Hanns H Lochmüller, Tuomo T Polvikoski, Roger G RG Whittaker, Angela A Pyle, Helen H Griffin, Robert W RW Taylor, et al.

Indexed on: 09 Mar '18

Published on: 09 Mar '18 in Genetics in Medicine

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[New] First description of a novel mitochondrial mutation in the MT-TI gene associated with multiple mitochondrial DNA deletion and depletion in family with severe dilated mitochondrial cardiomyopathy

Research paper by Olfa Alila-Fersi, Mouna Tabebi; Marwa Maalej; Neila Belguith; Leila Keskes; Emna Mkaouar-Rebai; Faiza Fakhfakh

Indexed on: 02 Mar '18

Published on: 26 Feb '18 in Biochemical and Biophysical Research Communications

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[New] Hypertrophic cardiomyopathy: a vicious cycle triggered by sarcomere mutations and secondary disease hits.

Research paper by Paul P Wijnker, Vasco V Sequeira, Diederik D Kuster, Jolanda van der JV Velden

Indexed on: 02 Mar '18

Published on: 02 Mar '18 in Antioxidants & redox signaling

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[New] Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells.

Research paper by Sanford P C SPC Hsu, John S JS Kuo, Hsin-Chien HC Chiang, Hsin-Ell HE Wang, Yu-Shan YS Wang, Cheng-Chung CC Huang, Yi-Chun YC Huang, Mau-Shin MS Chi, Minesh P MP Mehta, Kwan-Hwa KH Chi

Indexed on: 23 Feb '18

Published on: 23 Feb '18 in Oncotarget

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[New] Deciphering the spectrum of Mitochondrial DNA Mutations in Hepatocellular Carcinoma using High throughput Sequencing ----Mitochondrial DNA in Hepatocellular Carcinoma.

Research paper by Chang C Yu, Xuefeng X Wang, Lifeng L Huang, Ying Y Tong, Lili L Chen, Hailong H Wu, Qiang Q Xia, Xiaoni X Kong

Indexed on: 22 Feb '18

Published on: 22 Feb '18 in Gene expression

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[New] Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis.

Research paper by Yasunori Y Masuike, Koji K Tanaka, Tomoki T Makino, Makoto M Yamasaki, Yasuhiro Y Miyazaki, Tsuyoshi T Takahashi, Yukinori Y Kurokawa, Kiyokazu K Nakajima, Masaki M Mori, Yuichiro Y Doki

Indexed on: 16 Feb '18

Published on: 16 Feb '18 in PloS one

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Mitochondrial DNA depletion

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[New] Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance.

[New] 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.

[New] Ethical implications of medical crowdfunding: the case of Charlie Gard.

[New] Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes.

[New] ONC201 kills breast cancer cells in vitro by targeting mitochondria.

[New] Endonuclease G promotes mitochondrial genome cleavage and replication.

[New] Right Brain: Withholding treatment from a child with an epileptic encephalomyopathy.

[New] Inositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients.

[New] Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells.

[New] Intracellular calcium is a rheostat for the STING signaling pathway.

[New] Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

[New] Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency.

[New] Characterization of the novel mitochondrial genome replication factor MiRF172 in Trypanosoma brucei .

[New] Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer.

[New] Retrospective natural history of thymidine kinase 2 deficiency.

[New] The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.

[New] The presence of rNTPs decreases the speed of mitochondrial DNA replication.

[New] High-throughput terrestrial biodiversity assessments: mitochondrial metabarcoding, metagenomics or metatranscriptomics?

[New] Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine

[New] Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells

[New] Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

[New] Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

[New] The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway.

[New] Ciprofloxacin triggers the apoptosis of human triple-negative breast cancer MDA-MB-231 cells via the p53/Bax/Bcl-2 signaling pathway.

[New] Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

[New] First description of a novel mitochondrial mutation in the MT-TI gene associated with multiple mitochondrial DNA deletion and depletion in family with severe dilated mitochondrial cardiomyopathy

[New] Hypertrophic cardiomyopathy: a vicious cycle triggered by sarcomere mutations and secondary disease hits.

[New] Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells.

[New] Deciphering the spectrum of Mitochondrial DNA Mutations in Hepatocellular Carcinoma using High throughput Sequencing ----Mitochondrial DNA in Hepatocellular Carcinoma.

[New] Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis.