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CURATOR

I have just finished my PhD degree in poultry nutrition and I am looking for a postdoctoral position

I would be very interested to improve my experiences about novel adjuvants, their mechanisms of action, their synergistic effects, teratogenic properties, disadvantages and especially using these components to reduce embryonic lethality from in ovo vaccination and to increase immunity of chicks.

PINBOARD SUMMARY

Formulation of adjuvants, safety considerations, understanding their mechanisms of action and side e

Adjuvants are an essential component of modern vaccine development. An adjuvant is an entity added to a vaccine formulation to ensure that robust immunity to the antigen is inoculcated. The inclusion of an adjuvant is typically vital for the efficacy of vaccines using subunit (pepdids, proteins and virus like particles) and DNA antigens. Furthermore, these components are used to reach the current new goals of preventing and/ or treating chronic infectious diseases and cancers. Adjuvants can be broadly divided into two classes, based on their principal mechanisms of action; the first class are Vaccine delivery systems that generally particulate and mainly function to target associated antigens into antigen presenting cells. The others are immunostimulatory adjuvants that predominantly derived from pathogens and often represent pathogen associated molecular patterns which activate cells of the innate immune system. Adjuvants induce cellular and humoral responses, in particular neutralizing antibodies that able to inhibit the binding of pathogens to their cellular receptors. Efficient Th1-immunity-inducing adjuvants are highly in demand. Such adjuvants promote good cell-mediated immunity against subunit vaccines that have low immunogenicity themselves. However, attempts to develop a new generation of adjuvants, which are essential for new vaccines, is important, but their use is limited because, little is known about their mechanisms of action and health risks.