INSPIRE-Senior Research Fellow, CSIR-Indian Institute of Chemical Technology
In vitro and in vivo exploration of pro-angiogenic property of nanomaterials for disease therapy
My doctoral research mainly focuses on (i) Design and development of pro-angiogenic nanomaterials including elucidation of underlying molecular mechanisms and signaling pathways, (ii) Toxicity, genotoxicity and pharmacokinetics studies of nanomaterials and (iii) Application of bioactive nanoparticles for therapeutic angiogenesis towards vascular ischemic diseases (limb and myocardial ischemia) therapy and tissue engineering approaches.
Abstract: The process of angiogenesis, involving generation of new blood vessels from the existing ones, is vital for the supply of oxygen and nutrients to various tissues of body system. Angiogenesis is directly associated with several physiological and pathological processes. It is well-established that impairment in angiogenesis process results in various fatal conditions. Recently, few research groups including ours demonstrated therapeutic angiogenesis through nanomedicine approach using metal oxide/hydroxide nanoparticles. However, there is still a thorough necessity for the development of novel, eco-friendly, pro-angiogenic nanomaterials. Hence, in the present study we demonstrate the in vitro and in vivo pro-angiogenic properties of terbium hydroxide nanorods (THNRs) synthesized using an advanced microwave irradiation method, along with the detailed molecular signaling cascade underlying THNRs induced angiogenesis. The in vivo wound healing and nonimmunogenicity of the THNRs have been validated in the mouse models. We thus strongly believe that the present study establishing the pro-angiogenic properties of THNRs will aid in the development of alternative treatment strategies for wound healing along with cardiovascular and ischemic diseases, where angiogenesis is the chief target.
Pub.: 15 Nov '17, Pinned: 17 Jan '18
Abstract: We have designed and developed novel pro-angiogenic bio-synthesized gold nanoconjugates (b-Au-HP) that make new blood vessels, as observed by several in vitro and in vivo assays, suggesting their future potential applications in alternative treatment strategies for wound healing, cardiovascular diseases (CVD) and ischemic diseases using a nanomedicine approach.
Pub.: 10 Oct '14, Pinned: 17 Jan '18