3rd Year PhD student, Manchester Institute of Biotechnology, The University of Manchester
The development of highly sensitive biosensor using acrylate hydrogel for detection of bacteria
This research is to develop an optical instrument, a leap wave leaking sensor (MCLW) by using acrylate-based hydrogel as a sensing layer to detect the presence of microorganisms, bacteria or derivatives for safety and health monitoring applications. Since the device is constructed using biorecognition species to perform the detection, the device is considered a biosensor allowing for rapid detection of samples at low initial concentrations by using optical signals as transducers. The description of this research relies on acrylate-based hydrogel mechanisms for strong bonding with the device and porous hydrogel properties. Because the structure of the hydrogel shaft allows the sampled sample to reach the strong point of the optical band in the sensing layer, thereby producing a better signal to the sensor. In addition, the simplicity of the sensor is designed and the stability of the device to detect at room temperature with the shortest tracking duration compared to other biosensors that make this sensor applicable for use for applications in the field. The designed sensors also involve multiple channels to enable simultaneous detection of various bacteria such as E.colli, Salmonella and S.aures to detect using a single sample analysis, thereby saving the detection time and reducing the costs. The innovation of the sensor can help the world to control the safety and health of the netizen, especially when dealing with a spectacularly portable virus such as in the airport or borderline area, thus enabling the government to stop the spreading viruses, especially from the infected and risky country. In addition, the sensor also can be implemented to monitor the quality of indoor air and potable water, detecting spoilage in the food industries, controlling contamination in fossil and nuclear power plants, wastewater treatment plants and in the military and defensive forces.
Abstract: Thousands of billions of dollars have been disbursed worldwide for the diagnosis and therapy of disease. Nanobioscience combined with sensing technology has facilitated the pathway to diagnosis by introducing a novel, highly sensitive and selective detection system known as the nanobiosensor to reduce the overall cost of treatment. Among the many types of biosensors, optical ones are more easily developed because of their low cost, rapid construction, small size, high performance, high sensitivity and selectivity, high signal-to-noise ratio, flexible geometry, and portability properties. This study reviews and discusses nanobiosensors and electrochemical biosensors with the main focus on colorimetric, fluorometric, luminometric, fiber optic, and surface plasmon resonance-based optical biosensors and an emphasis on their applications in medical diagnosis.
Pub.: 03 Oct '17, Pinned: 12 Oct '17
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