A pinboard by
Hirak Patra

Marie Curie Individual European Fellow, University of Cambridge


The quest for transition from conventional medicine to personalised medicine

The concept of ‘Theranostics’ is shifting the paradigm of therapeutic approaches more towards patient-oriented and personalised care. Theranostic process is advanced solicitations of integrated material properties to clinical medicine for synchronized diagnosis and therapy. The success and implementation of personalized medicine is highly depending on the success of theranostics where functional drugs will be anchored as “companion” with the in-built diagnostic system to precisely govern whether the patient will get benefit from the specific treatment. The designing of the system could further be explored even to monitor the therapeutic progression and curative efficacy in real time. The hypothesis involves on site diagnosis and directed therapy in an inter-reliant, co-operative individual profile based way for personalised treatment. Furthermore, it postulates a transition from conventional medicine to personalized medicine based on the efficacy of on-spot diagnosis that require today to combat complex heterogeneous disease like cancer. The lecture will therefore highlight how systematic impost of theranostics needed appropriate decision making process. More comprehensive information transfer and knowledge exchange strategy are required across the scale to apprehend both sensing and ‘switch on’ the functions by which such information will be translated. There are number of critical interfaces across which respective triggering are obligatory to transfer the information within the theranostics system engaged into the decision-making process.

Patra, H. K. et al., Order-disorder micellar nanostructure…Adv. Health. Mat., 3(4), 526-535 (2014). Patra, H. K. et al., On/off-switchable anti-neoplastic nanoarchitecture. Scientific reports, 5 (2016).


Inflammation-sensitive in situ smart scaffolding for regenerative medicine.

Abstract: To cope with the rapid evolution of the tissue engineering field, it is now essential to incorporate the use of on-site responsive scaffolds. Therefore, it is of utmost importance to find new 'Intelligent' biomaterials that can respond to the physicochemical changes in the microenvironment. In this present report, we have developed biocompatible stimuli responsive polyaniline-multiwalled carbon nanotube/poly(N-isopropylacrylamide), (PANI-MWCNT/PNIPAm) composite nanofiber networks and demonstrated the physiological temperature coordinated cell grafting phenomenon on its surface. The composite nanofibers were prepared by a two-step process initiated with an assisted in situ polymerization followed by electrospinning. To obtain a smooth surface in individual nanofibers with the thinnest diameter, the component ratios and electrospinning conditions were optimized. The temperature-gated rearrangements of the molecular structure are characterized by FTIR spectroscopy with simultaneous macromolecular architecture changes reflected on the surface morphology, average diameter and pore size as determined by scanning electron microscopy. The stimuli responsiveness of the nanofibers has first been optimized with computational modeling of temperature sensitive components (coil-like and globular conformations) to tune the mechanism for temperature dependent interaction during in situ scaffolding with the cell membrane. The nanofiber networks show excellent biocompatibility, tested with fibroblasts and also show excellent sensitivity to inflammation to combat loco-regional acidosis that delay the wound healing process by an in vitro model that has been developed for testing the proposed responsiveness of the composite nanofiber networks. Cellular adhesion and detachment are regulated through physiological temperature and show normal proliferation of the grafted cells on the composite nanofibers. Thus, we report for the first time, the development of physiological temperature gated inflammation-sensitive smart biomaterials for advanced tissue regeneration and regenerative medicine.

Pub.: 08 Oct '16, Pinned: 26 Jun '17