MD/PhD Candidate, Northwestern University
I'm using a new imaging technology called OCT angiography, which provides high-resolution images of the microvasculature in the back of the eye. With this technology, I'm investigating how various retinal diseases change the retinal microvessels over time. These diseases include diabetic retinopathy, age related macular degeneration, and retinal vein occlusions. Hopefully, our work will provide valuable information about how vision can be best saved when patients present with these conditions.
Abstract: Siyu Chen, Qi Liu, Xiao Shu, Brian Soetikno, Shanbao Tong, Hao F. ZhangVisible-light optical coherence tomography (Vis-OCT) is an emerging technology that can image hemodynamic response in microvasculature. Vis-OCT can retrieve blood oxygen saturation (sO_2) mapping using intrinsic optical absorption contrast while providing high-resolution anatomical vascular ... [Biomed. Opt. Express 7, 3377-3389 (2016)]
Pub.: 01 Sep '16, Pinned: 18 Aug '17
Abstract: To investigate inner retinal oxygen metabolic rate (IRMRO2) during early stages of type 1 diabetes in a transgenic mouse model.In current study, we involved seven diabetic mice (Akita/+, TSP1-/-) and seven control mice (TSP1-/-), and applied visible-light optical coherence tomography (vis-OCT) to image functional parameters including retinal blood flow rate, oxygen saturation (sO2) and the IRMRO2 value longitudinally from 5 weeks of age to 13 weeks of age. After imaging at 13 weeks of age, we analyzed the imaging results, and examined histology of mouse retina.Between diabetic mice and the control group, we observed significant differences in venous sO2 from 9 weeks of age (P = 0.006), and significant increment in IRMRO2 from 11 weeks of age (P = 0.001) in diabetic mice compared with control group. We did not find significant differences in retinal blood flow rate as well as arterial sO2 during imaging between diabetic and control mice. Histologic examination of diabetic and control mice at 13 weeks of age also revealed no anatomical retinal alternations.In diabetic retinopathy, complications in retinal oxygen metabolism may occur before changes of retinal anatomical structure.
Pub.: 24 May '17, Pinned: 18 Aug '17
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