Postdoctoral Fellow, Yale University
Transformina drug delivery polymer into a structural device for diabetic wound healing
My research is currently investigating novel biodegradable materials to accelerate wound healing in diabetic patients. The project involves the synthesis and characterization of a three component polymer known as Poly(amine-co-ester) (PACE). PACE has demonstrated superior biocompatibility and to better facilitate the delivery of genetic materials, especially siRNA, compared to other commercially available transfection agents. This polymer is unique in that is has a slight cationic charge and controllable hydrophobicity which is governed by the synthesis component parts and their ratios. The aims of the research include exploring various synthesis components and their ratios to optimize PACE for extended delivery of siRNA and the generation of a scaffold as a biodegradable wound dressing. PACE has not prior been transformed into a structural device but has been well investigate for gene and drug delivery applications. The efficacy and safety of these siRNA delivering scaffolds will be assessed both in in-vitro and in-vivo.
Abstract: We aimed to investigate the differences in clinical characteristics and pharmacological treatment associated with the presence of diabetes in a large cohort of patients with dementia.A cross-sectional registry-based study was conducted using data from the Swedish Dementia Registry (SveDem). Data on dementia diagnosis, dementia type, and demographic determinants were extracted from SveDem. Data from Swedish Patient Register and Prescribed Drug Register were combined for the diagnosis of diabetes. Data on antidiabetic, dementia, cardiovascular, and psychotropic medication were extracted from the Swedish Prescribed Drug Register. Logistic regression was used to determine whether the variables were associated with diabetes after adjustment for confounders. In total, 29,630 patients were included in the study, and 4,881 (16.5%) of them received a diagnosis of diabetes.In the fully adjusted model, diabetes was associated with lower age at dementia diagnosis (odds ratio [OR] 0.97 [99% CI 0.97-0.98]), male sex (1.41 [1.27-1.55]), vascular dementia (1.17 [1.01-1.36]), and mixed dementia (1.21 [1.06-1.39]). Dementia with Lewy bodies (0.64 [0.44-0.94]), Parkinson's disease dementia (0.46 [0.28-0.75]), as well as treatment with antidepressants (0.85 [0.77-0.95]) were less common among patients with diabetes. Patients with diabetes who had Alzheimer's disease obtained significantly less treatment with cholinesterase inhibitors (0.78 [0.63-0.95]) and memantine (0.68 [0.54-0.85]).Patients with diabetes were younger at dementia diagnosis and obtained less dementia medication for Alzheimer's disease, suggesting less optimal dementia treatment. Future research should evaluate survival and differences in metabolic profile in patients with diabetes and different dementia disorders.
Pub.: 29 Jun '17, Pinned: 29 Jun '17
Abstract: Polyelectrolyte complex nanoparticles (PEC NPs) were fabricated via electrostatic interactions between positively charged heat-denatured lactoferrin (LF) particles and negatively charged pectin. The obtained PEC NPs were then utilized as curcumin carriers. PEC NPs were prepared by mixing 1.0 mg/mL solutions of heat-denatured LF and pectin at a mass ratio of 1:1 (w/w) in the absence of NaCl at pH 4.50. PEC NPs that were prepared under optimized conditions were spherical in shape with a particle size of ~208 nm and zeta potential of ~-32 mV. Hydrophobic curcumin was successfully encapsulated into LF/pectin PEC NPs with high encapsulation efficiency (~85.3%) and loading content (~13.4%). The in vitro controlled release and prominent antioxidant activities of curcumin from LF/pectin PEC NPs were observed. The present work provides a facile and fast method to synthesize nanoscale food-grade delivery systems for the improved water solubility, controlled release, and antioxidant activity of hydrophobic curcumin.
Pub.: 29 Jun '17, Pinned: 29 Jun '17
Abstract: The translation of small molecule chemistries into efficient methodologies for polymer functionalization spans several decades, enabling critical advances in soft matter materials synthesis with tailored and adaptive property profiles. The present Perspective explores—based on selected examples—50 years of innovation in polymer functionalization chemistries. These span a diverse set of chemistries based on activated esters, thiol–ene/yne processes, nucleophilic systems based on isocyanates, reactions driven by the formation of imines and oximes, ring-opening processes, cycloadditions, and—in a recent renaissance—multicomponent reactions. In addition, a wide variety of chain types and architectures have been modified based on the above chemistries, often with exquisite chemical control, highlighted by key examples. We conclude our journey through polymer functionalization with the—in our view—most critically required advances that have the potential to move from “science fiction” to “science fact”.
Pub.: 26 Jun '17, Pinned: 29 Jun '17
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