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CURATOR
A pinboard by
IBRAHIM MUSA

ASSISTANT LECTURER, KOGI STATE UNIVERSITY

PINBOARD SUMMARY

High serum bilirubin in the trained induced training bradycardia via inflammation process

The purpose of this study was to examine the effects on training induced-bradycardia. Anthropometric parameters, serum total bilirubin and leukocyte counts were measured in fasting state at rest. The VO2Max was estimated from a standard regression equation.High serum bilirubin in the trained induced training bradycardia via inflammation process

3 ITEMS PINNED

Multitarget botanical pharmacotherapy in major depression: a toxic brain hypothesis.

Abstract: A significant number of patients with major depression do not respond optimally to current antidepressant drugs. As depression is likely to be a heterogeneous disorder, it is possible that existing neurotransmitter-based antidepressant drugs do not fully address other pathologies that may exist in certain cases. Biological pathologies related to depression that have been proposed and studied extensively include inflammation and immunology, hypercortisolemia, oxidative stress, and impaired angiogenesis. Such pathologies may induce neurodegeneration, which in turn causes cognitive impairment, a symptom increasingly being recognized in depression. A neurotoxic brain hypothesis unifying all these factors may explain the heterogeneity of depression as well as cognitive decline and antidepressant drug resistance in some patients. Compared with neurotransmitter-based antidepressant drugs, many botanical compounds in traditional medicine used for the treatment of depression and its related symptoms have been discovered to be anti-inflammatory, immunoregulatory, anti-infection, antioxidative, and proangiogenic. Some botanical compounds also exert actions on neurotransmission. This multitarget nature of botanical medicine may act through the amelioration of the neurotoxic brain environment in some patients resistant to neurotransmitter-based antidepressant drugs. A multitarget multidimensional approach may be a reasonable solution for patients resistant to neurotransmitter-based antidepressant drugs.

Pub.: 29 Jun '17, Pinned: 30 Jun '17