PhD student, Indian Institute of Technology Bombay
Computational and mathematical techniques to biological research.
I am currently working towards a PhD. in Computational Neurophysiology at the Indian Institute of Technology Bombay (IIT Bombay), Mumbai, India. I am interested in the application of computational and mathematical techniques to biological research. As the boundaries between various disciplines keep reducing, an interdisciplinary approach seems to be the key to understanding our most challenging problems. My PhD thesis is concerned with developing mathematical models for spike generation in excitatory cells like detrusor smooth muscle and neuronal cells. Some partial results of my research are published in two journals and five conference proceedings. All final research results are documented for submission in two journal papers. My modeling approaches are related to ion channels, calcium dynamics and neurotransmitter releasing profile in cellular level. As the generation of action potential is essential in all excitable cells, I am extending my modeling skills into multi-compartmental model of sub thalamic neuronal cells with respect to neurodegenerative diseases. Describing systems in a quantitative manner means their behavior can be better simulated, and hence properties can be predicted that might not be evident to the experimenter.
Abstract: Current steering and current focusing are stimulation techniques designed to increase the number of distinct perceptual channels available to cochlear implant (CI) users by adjusting currents applied simultaneously to multiple CI electrodes. Previous studies exploring current steering and current focusing stimulation strategies are reviewed, including results of research using computational models, animal neurophysiology, and human psychophysics. Preliminary results of additional neurophysiological and human psychophysical studies are presented that demonstrate the success of current steering strategies in stimulating auditory nerve regions lying between physical CI electrodes, as well as current focusing strategies that excite regions narrower than those stimulated using monopolar configurations. These results are interpreted in the context of perception and speech reception by CI users. Disparities between results of physiological and psychophysical studies are discussed. The differences in stimulation used for physiological and psychophysical studies are hypothesized to contribute to these disparities. Finally, application of current steering and focusing strategies to other types of auditory prostheses is also discussed.
Pub.: 27 May '08, Pinned: 16 Aug '17