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Forgetting small things is not always related to Alzheimer. Several things can lead to it.
In 10 seconds? The memory loss can be triggered by different aspects. For example, a person involved in a car accident can present amnesia and sometimes lose their recent memories. However, the most common reason is aging.
What is the relation between aging and memory loss? As we are living longer, memory loss is a phenomenon increasing in number. Typically aging leads to a certain degree of memory loss that doesn’t prevent people on having a productive life. In fact, those kind of episodes can be also observed in young people under stress circumstances. The problem is when this memory loss progress to dementia like in the case of Alzheimer’s disease.
Abstract: The aging process has been associated with numerous pathologies at the cellular, tissue, and organ level. Decline or loss of brain functions, including learning and memory, is one of the most devastating and feared aspects of aging. Learning and memory are fundamental processes by which animals adjust to environmental changes, evaluate various sensory signals based on context and experience, and make decisions to generate adaptive behaviors. Age-related memory impairment is an important phenotype of brain aging. Understanding the molecular mechanisms underlying age-related memory impairment is crucial for the development of therapeutic strategies that may eventually lead to the development of drugs to combat memory loss. Studies in invertebrate animal models have taught us much about the physiology of aging and its effects on learning and memory. In this review we survey recent progress relevant to conserved molecular pathways implicated in both aging and memory formation and consolidation.
Pub.: 14 Jun '14, Pinned: 15 Apr '17
Abstract: Aging is known to be associated with a decrease of learning and memory. Little is known on the specificity of this process. In Drosophila, two forms of consolidated memory have been observed. Anesthesia-resistant memory (ARM) is formed after one or several consecutive training sessions whereas long-term memory (LTM) is formed only after multiple training sessions separated in time. Both memory forms last more than 24 h. In the present experiment I, address the question of the effect of aging on the formation of each memory form. Twenty four hours after being conditioned, old flies show similar ARM as young flies but LTM was completely abolished. Age memory impairment seems therefore to be specific to one consolidated memory form.
Pub.: 25 Jul '06, Pinned: 15 Apr '17
Abstract: Age-related memory impairment (AMI) is a phenomenon observed from invertebrates to human. Memory extinction is proposed to be an active inhibitory modification of memory, however, whether extinction is affected in aging animals remains to be elucidated. Employing a modified paradigm for studying memory extinction in fruit flies, we found that only the stable, but not the labile memory component was suppressed by extinction, thus effectively resulting in higher memory loss in aging flies. Strikingly, young flies were able to fully restore the stable memory component 3 h post extinction, while aging flies failed to do so. In conclusion, our findings reveal that both accelerated extinction and impaired restoration contribute to memory impairment in aging animals.
Pub.: 07 Apr '15, Pinned: 15 Apr '17
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