Immune system is a miraculous creation; it is a complex system made of many diverse cells each working to maintain the life and protect from viral or bacterial infections. It’s fantastic for me to find out the mystery of immunity. Now, my research interest is consistent with my desire, we focus on G protein-coupled receptors and signal transduction in the regulation of inflammation. On one hand, we demonstrated that Gpr97 is dispensable for inflammation in development of asthma (PLoS One, 2015), as well as the chronic metabolic inflammation (Scientific Report, 2016). On the other hand, we found that toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release (Infection and Immunity, 2014), as well TLR induced UDP play an important role in protecting infection via P2Y6 (The Journal of Immunology, 2016). Furthermore, extracellular ATP is easily degraded in plasma, so we do a lot research on its secondary product, ADP. Our results show that Pathogen-associated molecular patterns induced ADP facilitates monocyte recruitment through P2Y12/13 receptors in bacterial infection (Cellular &Molecular Immunology, 2016), and ADP also plays a key role in development of local inflammation in RA. I hope that our findings can make sense for further investigation of GPCR-based drugs.
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