Research Scholar, GC University lahore
The aim of my the present study was to examine the effect of different environmental and agricultural parameters on the quality and biological activities of essential oils of Lamiaceae species. The essential oils contents from material collected from colder regions and at full bloom were higher than from temperate regions. The GC-MS analysis revealed that mostly quantitative, rather than qualitative variations were observed in the oil composition of each species with respect to harvest seasons. The principal chemical constituent determined in M. arvensis, M. piperita, M. longifolia, M. spicata essential oils from both the seasons were menthol, menthone, piperitenone oxide and carvone, respectively. The major chemical constituent of O. sanctum, O. gratissimum and O. basilicum essential oils were eugenol, β-caryophyllene, β-elemene and linalool. The antiproliferative activity has been tested on breast cancer MCF-7 and prostate cancer LNCaP cell lines by the MTT assay. The antimicrobial and antioxidant activities were determined by using broth micro dilution, DPPH radical-scavenging and inhibition of linoleic acid oxidation assays. All the tested essential oils exhibited excellent antimicrobial, antioxidant, cytotoxic potentials. The significant (p < 0.05) variations in the contents of most of the chemical components and biological activities of seasonally collected samples were documented.