LECTURER 1, UNIVERSITY OF NIGERIA, NSUKKA
In search of a natural, available, acceptable, accessible and safe management of diabetes mellitus
This study was designed to determine the effect of consumption of turmeric rhizome (Curcuma longa) powder on the haematological and histological properties of induced diabetic adult male rats. Acute toxicity result showed that no death occurred in the mice up to a dose of 5000mg/kgBW. Twenty (20) adult male rats weighing 150-180g used for the study were grouped based on their body weight into four groups (A, B, C and D) comprising five rats each. Diabetes was induced using alloxan monohydrate. Rats in groups A (control), B, C and D were fed orally with 0mg /kg BW, 1000mg/kg BW, 3000mg/kg BW and 5000mg/kg BW of sun-dried pulverised turmeric rhizome daily respectively for 21 days. The rats received normal food and water ad libitum throughout the experiment. Proximate composition of the turmeric rhizome powder showed carbohydrate (69.12%), fats (2.46%), moisture (5.50%), protein (10.27%), crude fibre (7.26%) and ash (5.37%). Blood glucose levels after treatment showed percentage decrease in mean values of groups B, C and D. The effect of the treatment was dose-dependent across all the groups. The treatment was significantly (p < 0.05) effective and highest in group D than other groups. The haematological parameters after treatment showed that the packed cell volume, red blood cell and haemoglobin of the treated groups had higher percentage increase when compared with the control group. Group D showed a significant (p < 0.05) dose dependent increase. There was a percentage decrease (8.48% - 11. 99%) in the white blood cell across all the groups. Histological analysis showed no damage on the liver and pancreas of all the treated rats compared to the control group which had an inflamed pancreas. It could be concluded that turmeric rhizome powder in addition to its hypoglycaemic and anti-inflammatory effect also has immune and blood boosting properties while maintaining both liver and pancreas health. This indicates that turmeric can safely be incorporated into the diet of diabetic patients.