Research assistant, Zewail City of Science and Technology
The effect of diabetic microenvironment on human adipose stem cells regenerative potential
Diabetes mellitus (DM) is a chronic disease due to defect in production of insulin hormone from Beta-cells of pancreas or the body cannot use the insulin effectively. Insulin hormone is responsible for regulating of blood sugar. Hyperglycemia, or raised blood sugar, is a common effect of uncontrolled diabetes and over time leads to serious damage to many of the body systems, especially the nerves and blood vessels. Data from International diabetes federation showed that DM affects more than 300 million people worldwide, causing substantial morbidity and mortality. Furthermore, nearly half of the deaths before age of 70 due to high blood glucose. Stem cells are an undifferentiated cell which have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive . Stem cell therapy holds immense promise for the treatment of patients with diabetes mellitus. Adipose stem cells are adult stem cells isolated from adipose tissue and were proven of great capacity to treat diabetes and its complications. However, diabetic microenvironment is hostile and can damage these cells. Thus we study how diabetes affect the regenerative capacity of these cells in order to develop therapeutics that enhance their regenerative potential, making the adipose tissue a good source of autologous stem cells transplantation.