Lecturer, Afe Babalola University
Studies on Novel Biomarkers for Early Detection of Early Onset Breast Cancer
Background: Breast cancer is the most common life-threatening malignant lesion in women of many countries, with approximately 180,000 new cases diagnosed every year. It causes the highest mortality due to cancers in Nigeria among women. Currently, the diagnostic workup for breast cancer includes mammography; breast self examination (BSE) and clinical breast examination (CBE). Suspected cases are often sent for breast biopsy and histopathology investigation. Although BSE and CBE methods are inexpensive, they offer low diagnostic sensitivity and specificity; while mammography method is expensive. At present, there is no specific marker for breast cancer diagnosis in Nigeria. The most widely used serum marker for monitoring recurrent breast cancer, especially following remission is the CA15-3 protein. Therefore, novel tumour markers are still required for early detection of breast cancers in resource limited settings.
Aim : To detect novel biomarkers for early diagnosis of breast cancer
Method : In this research, the pattern of protein expression in breast tissue, serum and urine of informed consented participants will be investigated using novel proteomic methods for discovering and validating novel biomarkers that might be used for early detection of breast cancer shall be employed.
Results and Conclusion: Conclusion shall be drawn from the results obtained