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CURATOR
A pinboard by
Reham Atteya

PhD student, Zewail City of Science and Technology

PINBOARD SUMMARY

DNA is the hereditary material in living organisms that decides for their fate and therefore, it has to be accurately preserved. When cells encounter DNA damage, it should be rapidly repaired otherwise, the organism has to face a lot of negative consequences. DNA damage is linked to a various range of diseases including neurodegenerative diseases such as Alzheimer and Parkinson’s, mitochondrial dysfunction and premature aging. In addition, DNA damage is also linked to all cancer types including liver and breast cancers; the two most prevalent cancers among men and women in Egypt, respectively. The most common DNA damage type is ribonucleotides (rNTPs) misincorporation in the DNA consisting only of deoxyribonucleotides. This kind of damage is linked to gene mutations, chromosomal aberration, replication fork stalling, neurodegenerative diseases and hypothesized to be linked to cancer. The misincorporated rNTPs are mainly removed from the genome by enzymes known as Ribonucleases H1 and 2 (RNase H1 and RNase H2). Our research group is particularly interested in the mechanisms that prevent ribonucleotides incorporation in the genome and the mechanisms that repair this kind of damage when it takes place.

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