A pinboard by
Rui Li

Phd Candidate, The University of Melbourne


The project contributes to a seizure-free post surgical results for focal epilepsy patients.

Epilepsy is a brain disorder that introduces unpredictable epileptic seizures, which can contribute to bodily injuries and even death. In 2013, around 65 million people in the world have epilepsy, among which 40% of patients are not adequately treated by drugs. These patients have clinical symptoms indicating their disorder can be traced to a small region of damaged brain tissue (focal epilepsy), and they can potentially profit from surgical resection of that region. Averagely, 60% of patients who were operated on in this way became seizure-free. However, patients with focal epilepsy can take advantages from surgical resection only if the epileptogenic zone (EZ), defined as minimum region of cortical surface that must be eradicated to ensure seizure free outcome, can be accurately defined. Therefore, accurate localisation of the EZ is crucial for good postsurgical outcomes. This project is promising to help patients who failed to achieve accurate EZ from traditional recording modalities, such as EEG (electroencephalography), PET (positron emission tomography) and SPECT (single-photon emission computed tomography). Since the MEG has the time resolution as high as EEG, but can provide complementary information from EEG and is less sensitive to brain tissue distortion than EEG. Moreover, neurophysiologists have to visually examine massive MEG (Megnetoencephalography) data to find EZ for patients in past. This project is determined to contribute to an automated approach, which could effectively reduce the period of identifying EZ and relieve neurophysiologists’ cumbersome manual works.


Magnetoencephalographic spike sources associated with auditory auras in paediatric localisation-related epilepsy.

Abstract: To characterise magnetoencephalographic spike sources in paediatric patients with auditory auras and recurrent localisation-related epilepsy.Six patients (four boys and two girls (ages 7-14 years) were retrospectively studied. All patients had auditory auras as part of their initial seizure manifestation, including four patients who underwent previous brain surgery. Scalp video electroencephalography and magnetoencephalography (MEG) were carried out in six patients, intraoperative electrocorticography in three patients and extraoperative intracranial video electroencephalography in one patient. MEG auditory-evoked fields (AEFs) were studied in four patients.Three patients had elementary auditory auras, one had complex auditory aura and two had both complex and elementary auras. All six patients had clustered MEG spike sources with coexisting scattered spike sources. MEG clusters were localised in the superior temporal gyrus with surrounding scatters in four patients (two left and two right); two patients had scattered spikes in the superior temporal gyrus in addition to clustered MEG spike sources in the left inferior and middle frontal gyri or parieto-occipital region. AEFs were located within an MEG cluster in one patient and within 3 cm of a cluster in two patients. Surgical resection, including the regions of MEG clusters, was carried out in four patients. Three of four patients who had previous surgeries were seizure free at 2 years after excision of the MEG cluster region.MEG spike sources clustered in the superior temporal gyrus in six patients with auditory auras. These spike sources were in close proximity or seemed to engulf the magnetic AEF. Areas with MEG spike sources contained the residual or recurrent epileptogenic zone after incomplete cortical excision for lesional epilepsy.

Pub.: 08 Aug '06, Pinned: 28 Jul '17

Continuous EEG source imaging enhances analysis of EEG-fMRI in focal epilepsy.

Abstract: EEG-correlated fMRI (EEG-fMRI) studies can reveal haemodynamic changes associated with Interictal Epileptic Discharges (IED). Methodological improvements are needed to increase sensitivity and specificity for localising the epileptogenic zone. We investigated whether the estimated EEG source activity improved models of the BOLD changes in EEG-fMRI data, compared to conventional < event-related > designs based solely on the visual identification of IED.Ten patients with pharmaco-resistant focal epilepsy underwent EEG-fMRI. EEG Source Imaging (ESI) was performed on intra-fMRI averaged IED to identify the irritative zone. The continuous activity of this estimated IED source (cESI) over the entire recording was used for fMRI analysis (cESI model). The maps of BOLD signal changes explained by cESI were compared to results of the conventional IED-related model.ESI was concordant with non-invasive data in 13/15 different types of IED. The cESI model explained significant additional BOLD variance in regions concordant with video-EEG, structural MRI or, when available, intracranial EEG in 10/15 IED. The cESI model allowed better detection of the BOLD cluster, concordant with intracranial EEG in 4/7 IED, compared to the IED model. In 4 IED types, cESI-related BOLD signal changes were diffuse with a pattern suggestive of contamination of the source signal by artefacts, notably incompletely corrected motion and pulse artefact. In one IED type, there was no significant BOLD change with either model.Continuous EEG source imaging can improve the modelling of BOLD changes related to interictal epileptic activity and this may enhance the localisation of the irritative zone.

Pub.: 02 Dec '09, Pinned: 28 Jul '17

Sensitivity of scalp 10-20 EEG and magnetoencephalography.

Abstract: Although previous studies have investigated the sensitivity of electroencephalography (EEG) and magnetoencephalography (MEG) to detect spikes by comparing simultaneous recordings, there are no published reports that focus on the relationship between spike dipole orientation or sensitivity of scalp EEG/MEG and the "gold standard" of intracranial recording (stereotactic EEG). We evaluated two patients with focal epilepsy; one with lateral temporal focus and the other with insular focus. Two MEG recordings were performed for both patients, each recorded simultaneously with initially scalp EEG, based on international 10-20 electrode placement with additional electrodes for anterior temporal regions, and subsequently stereotactic EEG. Localisation of MEG spike dipoles from both studies was concordant and all MEG spikes were detected by stereotactic EEG. For the patient with lateral temporal epilepsy, spike sensitivity of MEG and scalp EEG (relative to stereotactic EEG) was 55 and 0%, respectively. Of note, in this case, MEG spike dipoles were oriented tangentially to scalp surface in a tight cluster; the angle of the spike dipole to the vertical line was 3.6 degrees. For the patient with insular epilepsy, spike sensitivity of MEG and scalp EEG (relative to stereotactic EEG) was 83 and 44%, respectively; the angle of the spike dipole to the vertical line was 45.3 degrees. For the patient with lateral temporal epilepsy, tangential spikes from the lateral temporal cortex were difficult to detect based on scalp 10-20 EEG and for the patient with insular epilepsy, it was possible to evaluate operculum insular sources using MEG. We believe that these findings may be important for the interpretation of clinical EEG and MEG.

Pub.: 28 Mar '13, Pinned: 28 Jul '17