PhD student-full time, University of Hong Kong
bone tissue engineering
i am a graduate of oral and maxillofacial surgery from Prince of Songkla University (Thailand). Beside my clinical interest in maxillofacial reconstruction and traumatology, i have started my research activities on biomaterials with focus on novel biomaterials for bone tissue engineering. i have produced new technique for production of biphasic bioceramics scaffolds during my MSc program in 2010 and it was published and presented in international conference. i have been working in collaboration with different research centers and universities including National Metal and Materials Technology center (MTEC, Thailand) and King’s college (UK). i am currently working as a researcher and PhD candidate at Prince Philip Dental Hospital (University of Hong Kong). my research interests include synthesis of nano bioceramics with controlled physico-chemical properties, fabrication of novel biphasic calcium phosphate scaffolds for enhanced bone tissue engineering and more recently development of novel hybrid nano bioceramics (collagen and HA) with customized topography as a potential carrier for signaling molecules for enhanced bone regeneration. I am also working on stem cell from dental and oral origin and trying to guide them into bone forming cells through incorporation with new scaffolds.
i have presented my works at different local and international conferences and published several papers in peer reviewed journals.
Abstract: Biphasic calcium phosphates (BCP) bioceramics have become the materials of choice in various orthopedic and maxillofacial bone repair procedures. One of their main advantages is their biodegradation rate that can be modified by changing the proportional ratio of the composition phases. For enhanced bone tissue regeneration, the bioactivity of BCP should be increased by optimizing their physicochemical properties. To date, the ideal physicochemical properties of BCP for bone applications have not been defined. This is mostly related to lack of standard study protocols in biomaterial science especially with regards to their characterizations and clinical applications. In this paper we provided a review on BCP and their physicochemical properties relevant to clinical applications. In addition, we summarized the available literature on their use in animal models and evaluated the influences of different composition ratios on bone healing. Controversies in literature with regards to ideal composition ratio of BCP have also been discussed in detail. We illustrated the discrepancies in study protocols among researchers in animal studies and emphasized the need to develop and follow a set of generally accepted standardized guidelines. Finally; we provided general recommendations for future pre-clinical studies that allow better standardization of study protocols. This will allow better comparison and contrast of newly developed bone substitute biomaterials that help further progress in the field of biomaterial science.
Pub.: 12 Nov '16, Pinned: 25 Aug '17
Abstract: The data presented in this article are related to the research article entitled “Biphasic calcium phosphates bioceramics (HA/TCP): Concept, physicochemical properties and the impact of standardization of study protocols in biomaterials research” . This article provides in depth study of BCP bone substitutes as valuable option in the field of tissue engineering. However, there are discrepancies in the literature regarding the ideal physicochemical properties of BCP and the ideal balance between different phase compositions for enhanced bone tissue engineering (M. Ebrahimi, M.G. Botelho, S.V. Dorozhkin, 2016; M. Ebrahimi, P. Pripatnanont, S. Suttapreyasri, N. Monmaturapoj, 2014) [1,2]. This is found to be mainly because of improper characterization of BCP bioceramics in basic studies and lack of standard study protocols in in vitro and in vivo research. This data article along with original article provide the basic data required for ideal characterization of BCP and other bioceramics in an attempt to provide basic standardized protocols for future studies.
Pub.: 28 Nov '16, Pinned: 25 Aug '17
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