Computational methods for the design of effective therapies against drug resistant HIV strains.
Research paper by
Niko N Beerenwinkel, Tobias T Sing, Thomas T Lengauer, Jörg J Rahnenführer, Kirsten K Roomp, Igor I Savenkov, Roman R Fischer, Daniel D Hoffmann, Joachim J Selbig, Klaus K Korn, Hauke H Walter, Thomas T Berg, Patrick P Braun, Gerd G Fätkenheuer, Mark M Oette, Jürgen J Rockstroh, Bernd B Kupfer, Rolf R Kaiser, Martin M Däumer
The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.