Understanding the pharmacophore of P2X7R antagonists

Last updated 28th Aug 2017
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A pinboard by James O'Brien-Brown

PhD student, The University of Sydney


Synthesis of P2X7R antagonists in order to distinguish binding to orthosteric and allosteric sites

The P2X7 receptor (P2X7R) is believed to be a key mediator of inflammation in the brain (neuroinflammation) by releasing pro-inflammatory molecules such as interleukin 1-B (IL-1B). There has been s...