Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor an...
CURATOR
PhD student, The University of Sydney
PINBOARD SUMMARY
Synthesis of P2X7R antagonists in order to distinguish binding to orthosteric and allosteric sites
The P2X7 receptor (P2X7R) is believed to be a key mediator of inflammation in the brain (neuroinflammation) by releasing pro-inflammatory molecules such as interleukin 1-B (IL-1B). There has been s...
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