Understanding the pharmacophore of P2X7R antagonists

Last updated 28th Aug 2017
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A pinboard by James O'Brien-Brown

PhD student, The University of Sydney

PINBOARD SUMMARY

Synthesis of P2X7R antagonists in order to distinguish binding to orthosteric and allosteric sites

The P2X7 receptor (P2X7R) is believed to be a key mediator of inflammation in the brain (neuroinflammation) by releasing pro-inflammatory molecules such as interleukin 1-B (IL-1B). There has been s...