Structure of ring-shaped Aβ42 oligomers determined by conformational selection

Last updated 9th Dec 2017
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Based on the “conformational selection” paradigm for molecular recognition and self-organization

The oligomerization of amyloid beta (Aβ) peptides into soluble non-fibrillar species plays a critical role in the pathogenesis of Alzheimer’s disease. However, it has been challenging to characteri...