A Belgian consensus protocol for autologous hematopoietic stem cell transplantation in multiple sclerosis
Research paper by
Guy Laureys, Barbara Willekens, Ludo Vanopdenbosch, Olivier Deryck, Dominik Selleslag, Miguel D’Haeseleer, Ann De Becker, Bénédicte Dubois, Daan Dierickx, Gaetano Perrotta, Virginie De Wilde, Vincent van Pesch, Nicole Straetmans, Dominique Dive, Yves Beguin, Bart Van Wijmeersch, Koen Theunissen, Tessa Kerre, Ann Van de Velde
Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous hematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality, and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardized protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous hematopoietic stem cell transplantation in multiple sclerosis.