SOX17 deficiency impairs lung vasculature in pulmonary hypertension

Last updated 31st Mar 2020
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CURATOR

A pinboard by Joy Shih

Final Year PhD Student hoping to unravel the mystery of a rare and deadly lung disorder!

PINBOARD SUMMARY

Pulmonary hypertension is a disease caused by thickening of lung blood vessels leading to heart failure. Recently, we found defects in the SOX17 gene in PAH patients. Aim: To examine SOX17 function and understand how the gene defects cause disease.

WHY IS THE STUDY IMPORTANT?

Pulmonary arterial hypertension (PAH) is a fatal disease characterised by the narrowing of blood vessels in the lungs. The resulting increase in blood pressure leads to...