Arsenic and heavy metals are implicated in causation of CKDu among farmers in dry zone of Sri Lanka. Rice has been identified as a major source of arsenic in research carried out in other countries. We analyzed 120 samples of new improved varieties (NIVs) and 50 samples of traditional varieties (TV) of rice for total arsenic content.Rice cultivated in Sri Lanka is contaminated with arsenic. Agrochemical dependent NIVs contain considerable amount (20.6 -540.4 μg/Kg) of arsenic. There is no difference between the arsenic content in NIV rice samples from areas where there is high or low prevalence of CKDu. TVs that are cultivated without using agrochemicals contain significantly less arsenic (11.6 - 64.2 μg/Kg). However, it is evident that the TVs also contain toxic metals if they are grown with fertilizers and pesticides.A high proportion of arsenic in rice exists in the inorganic form. Sri Lanka is a nation with high per capita consumption of rice. Codex Alimentarius recommends the maximum allowable limit for inorganic arsenic in rice as 200 μg/kg. Assuming that 70% of the total arsenic content exists in the inorganic form, this corresponds to a level of about 286 μg/kg of total arsenic. As such, 11.6% of the samples of NIVs exceeded this maximum recommended level in polished rice. Inorganic arsenic is a non-threshold carcinogen. Research should be focused on developing rice varieties that do not retain arsenic within the rice grain.