We analyze the source-to-sink variations of in situ10Be, 26Al and 21Ne concentrations in modern sediment of the Po river catchment, from Alpine, Apennine, floodplain, and delta samples, in order to investigate how the cosmogenic record of orogenic erosion is transmitted across a fast-subsiding foreland basin. The in situ10Be concentrations in the analyzed samples range from ∼0.8×104 at/gQTZ∼0.8×104 at/gQTZ to ∼6.5×104 at/gQTZ∼6.5×104 at/gQTZ. The 10Be-derived denudation rates range from 0.1 to 1.5 mm/yr in the Alpine source areas and from 0.3 to 0.5 mm/yr in the Apenninic source areas. The highest 10Be-derived denudation rates are found in the western Central Alps (1.5 mm/yr). From these data, we constrain a sediment flux leaving the Alpine and the Apenninic source areas (>27 Mt/yr and ca. 5 Mt/yr, respectively) that is notably higher than the estimates of sediment export provided by gauging (∼10 Mt/yr at the Po delta).