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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

ABSTRACT

A single-cell atlas of human and mouse adipose tissue uncovers protective lipid-associated macrophages (LAMs), which perform lipid uptake and metabolism to prevent adipocyte hypertrophy, inflammation, and systemic metabolic dysregulation in a Trem2 signaling-dependent manner.