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Pancreatic islet xenotransplantation

ABSTRACT

Publication date: Available online 8 December 2017 Source:Drug Discovery Today: Disease Models Author(s): Melanie L. Graham, Henk-Jan Schuurman

This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.