A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.
Research paper by
Daniel C DC Leslie, Anna A Waterhouse, Julia B JB Berthet, Thomas M TM Valentin, Alexander L AL Watters, Abhishek A Jain, Philseok P Kim, Benjamin D BD Hatton, Arthur A Nedder, Kathryn K Donovan, Elana H EH Super, Caitlin C Howell, Christopher P CP Johnson, Thy L TL Vu, Dana E DE Bolgen, Sami S Rifai, Anne R AR Hansen, Michael M Aizenberg, Michael M Super, Joanna J Aizenberg, Donald E DE Ingber
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.