DNA sequence context influences the reaction mechanism of the polymerase beta

Last updated 3rd Jul 2017
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A pinboard by Khadijeh Alnajjar

Postdoctoral associate at Yale University. Biochemistry roles!

PINBOARD SUMMARY

A biochemical approach to understand how sequence-context affects errors made by polymerases

Certain genes in our genome are prone to high mutation frequency, creating signature hotspots, which are characteristic of certain cancers. Many of these hotspots have been identified, however, no ...