Decoding sequence-level information to predict membrane protein expression

Last updated 28th Jun 2017
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A pinboard by Shyam Saladi

Graduate Student, Caltech

PINBOARD SUMMARY

New computer-based methods to avoid failed experiments thereby accelerating protein structure

Membrane proteins play a pivotal role in biology, representing a quarter of all proteomes and a majority of drug targets. While considerable effort has been focused on improving our functional unde...

3 ITEMS PINNED

#1
Large tilts in transmembrane helices can be induced during tertiary structure formation.
Research published 6th May 2014 in Journal of M...
Pinned 28th Jun 2017
#2
Hydrophobic clusters raise the threshold hydrophilicity for insertion of transmembrane sequences in vivo.
Research published 14th Sep 2016 in Biochemistry
Pinned 28th Jun 2017
#3
Structurally detailed coarse-grained model for Sec-facilitated co-translational protein translocation and m...
Free access available
Research published 23rd Mar 2017 in PLoS comput...
Pinned 28th Jun 2017
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