Chemical Genetics-Based Cancer Drug Discovery Using Covalent Chemical Probes

Last updated 8th Aug 2017
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CURATOR

A pinboard by Dharmaraja AT

I'm a Postdoc working in the area of chemical biology at the School of Medicine, CWRU, Ohio, USA

PINBOARD SUMMARY

Revisiting electrophilic molecules as cancer therapeutics is encouraged both in industry & Academia

Drug discovery primarily relied on non-covalent small molecule inhibitors of proteins due to their high selectivity and safe in vivo cytotoxicity profiles. Irreversible inhibitors associated with i...