Zollinger-Ellison syndrome in a patient with normal screening gastrin level

Research paper by Randy J. Yanda, James W. Ostroff, Cameron D. Ashbaugh, Margaret S. Guis, Henry I. Goldberg

Indexed on: 01 Dec '89Published on: 01 Dec '89Published in: Digestive Diseases and Sciences


A 59-year-old female presented with multifocal peptic ulcer disease and diarrhea. A fasting serum gastrin level obtained while the patient was receiving no antacid therapy was normal. A secretin stimulation test was positive. A small gastrinoma was found in the anterior duodenal wall at exploratory laparotomy. Normal fasting gastrin levels do occur in patients with overt Zollinger-Ellison syndrome and should not deter further investigation if clinical suspicion of this syndrome is high.