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Zika Virus and Birth Defects - Reviewing the Evidence for Causality.

Research paper by Sonja A SA Rasmussen, Denise J DJ Jamieson, Margaret A MA Honein, Lyle R LR Petersen

Indexed on: 14 Apr '16Published on: 14 Apr '16Published in: The New England journal of medicine



Abstract

The Zika virus has spread rapidly in the Americas since its first identification in Brazil in early 2015. Prenatal Zika virus infection has been linked to adverse pregnancy and birth outcomes, most notably microcephaly and other serious brain anomalies. To determine whether Zika virus infection during pregnancy causes these adverse outcomes, we evaluated available data using criteria that have been proposed for the assessment of potential teratogens. On the basis of this review, we conclude that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Evidence that was used to support this . . .