Quantcast

Zijn combinaties van niet-narcotische analgetica rationeel?

Research paper by A. J. M. Seegers

Indexed on: 01 Dec '80Published on: 01 Dec '80Published in: Pharmacy world & science : PWS



Abstract

The main purpose of the animal experiments described in this thesis was to elucidate the manner in which interactions between non-narcotic analgesics contribute to the gastric erosive activity of some of their combinations, and to evaluate these interactions in relation to the antiinflammatory, analgesic and antipyretic activities of the drugs concerned.Caffeine potentiates the erosive activity of acetylsalicylic acid and of the combination of acetylsalicylic acid with phenacetin; on the other hand, paracetamol antagonises the erosive activity of acetylsalicylic acid and of the combination of acetylsalicylic acid with caffeine. Possible mechanisms underlying these interactions are discussed.The anti-inflammatory, analgesic and antipyretic activities of dual and triple combinations of acetylsalicylic acid, paracetamol, phenacetin and caffeine at least equal addition of the activities of the individual component drugs.The observed interactions are evaluated in relation to the current status of compound analgesics in clinical medicine; it is concluded that mixtures containing acetylsalicylic acid and caffeine are to be regarded as irrational whereas addition of phenacetin does not appear to offer any advantages. Whether a beneficial interaction between acetylsalicylic acid and paracetamol such as demonstrated on gastric mucosal damage in rats occurs in man remains to be established.