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ZIF nano-dagger coated gauze for antibiotic-free wound dressing.

Research paper by Yuan Y Yuan, Hong H Wu, Hongfang H Lu, Yiran Y Zheng, Jackie Y JY Ying, Yugen Y Zhang

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Chemical Communications



Abstract

Nano-dagger coated gauze was bactericidal against both Gram-positive and Gram-negative bacteria, with log reduction >7 for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available Ag gauze, the ZIF-L nano-dagger coated gauze was more biocompatible with a lower haemolytic activity, less cytotoxicity and improved wound healing performance. Animal studies showed that the ZIF-L coated gauze can effectively kill bacteria in a S. aureus wound infection model in mice. This novel nano-dagger coated gauze offers an effective and safe alternative for patients to protect against wound infections. This study demonstrates the first application of a MOF coating as an antibiotic-free wound dressing with potent antimicrobial activity and improved biocompatibility.