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Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity.

Research paper by Ryuji R Uchida, Rie R Imasato, Yuichi Y Yamaguchi, Rokuro R Masuma, Kazuro K Shiomi, Hiroshi H Tomoda, Satoshi S Omura

Indexed on: 29 Dec '06Published on: 29 Dec '06Published in: The Journal of Antibiotics



Abstract

New nine insecticidal antibiotics designated yaequinolones were isolated from the culture broth of the fungal strain Penicillium sp. FKI-2140 by solvent extraction, centrifugal partition chromatography and HPLC. Yaequinolones showed growth inhibitory activity against brine shrimp (Artemia salina). Among them, yaequinolone F has the most potent activity with MIC value of 0.19 microg/ml.