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Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers

Research paper by C. Martin, F. Gimenez, K. N. Bangchang, J. Karbwang, R. Farinotti, I. W. Wainer

Indexed on: 01 Aug '94Published on: 01 Aug '94Published in: European Journal of Clinical Pharmacology



Abstract

We studied the pharmacokinetics of the enantiomers of mefloquine in whole blood in healthy Thai volunteers after administration of a single oral dose of 750 mg of the racemic mixture.Mefloquine pharmacokinetics were stereoselective. The peak concentrations and areas under the curve of the (−) enantiomer were significantly higher than those of its antipode (0.79 versus 0.46 μg · ml-1 and 402 versus 94 μg · h · ml-1). The half-lives of (−)MQ were significantly longer than those of (+)MQ (531 versus 206 h). No stereoselectivity was observed for tmax values.

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