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Warfarin-Rifampin Drug Interaction in a Pediatric Patient.

Research paper by Michael M Poon, Brady S BS Moffett, Donald L DL Yee

Indexed on: 19 Oct '17Published on: 19 Oct '17Published in: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG



Abstract

Rifampin has been documented to significantly attenuate the effect of warfarin in adult patients. No data have been presented on the use of rifampin and warfarin in a pediatric patient. We report an extreme case of increased warfarin metabolism in a pediatric patient who was concomitantly receiving rifampin, despite receiving other medications that significantly decrease warfarin metabolism. The inhibitory effect of rifampin on warfarin therapy may be amplified in pediatric patients.