Vitamin D deficiency in pregnant women of ethnic minority: a potential contributor to preeclampsia.

Research paper by I V IV Reeves, Z D ZD Bamji, G B GB Rosario, K M KM Lewis, M A MA Young, K N KN Washington

Indexed on: 24 May '14Published on: 24 May '14Published in: Journal of Perinatology


We investigated risk for comorbidities and preeclampsia at low vitamin D levels in ethnic minorities.Umbilical cord vitamin D (25(OH)D) concentration was determined in urban minorities: 80.9% African American and 17% Hispanic mothers-baby pairs. To identify the correlation between vitamin D levels and high-risk comorbidities which result in preeclampsia, multivariate logistic regression analyses were performed.Below the Institute of Medicine threshold of 25(OH)D for pregnant women (25 ng ml⁻¹), obesity (P=0.055) and pregestational diabetes (odds ratio (OR)=2.056) were observed. The study median was 16 ng ml⁻¹ (<25th percentile), at which gestational hypertension (P=0.042), chronic hypertension (OR=4.842) and pregestational diabetes (OR=3.45) became relevant. The risk for preeclampsia increased 12-fold with gestational hypertension (P=0.003) and 14-fold with combined chronic and gestational hypertension (P=0.001).Pregnant women of ethnic minority had lower median vitamin D levels which may contribute to a potential risk for preeclampsia.