Viral loads of cerebrospinal fluid in infants with enterovirus meningitis.

Research paper by Hisashi H Kawashima, Hiroaki H Ioi, Chiako C Ishii, Yuka Y Hasegawa, Masahiro M Amaha, Yasuyo Y Kashiwagi, Kouji K Takekuma, Akinori A Hoshika, Yasuo Y Watanabe

Indexed on: 20 May '08Published on: 20 May '08Published in: Journal of Clinical Laboratory Analysis


For a better understanding of the role of the viral load, free radicals, and cytokines in viral meningitis, we surveyed cerebrospinal fluid (CSF) obtained from patients below 1 year of age who showed positive for enterovirus. In their first examinations interleukin (IL)-6 and free radicals increased whereas pleocytosis was rarely observed. IL-6 decreased within the short period. Viral loads and free radicals increased simultaneously. IL-6 and free radicals of CSF are helpful for diagnosis and treatment of viral meningitis at an early stage.