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Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy.

Research paper by Valerie V Sapp, Mohit M Jain, Ronglih R Liao

Indexed on: 03 Jun '16Published on: 03 Jun '16Published in: Physiology (Bethesda, Md.)



Abstract

Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.