Variability of surgical prophylaxis in penicillin-allergic children.

Research paper by David F DF Butler, Brian R BR Lee, Sarah S Suppes, Tracy T Sandritter, Jason G JG Newland, Lory L Harte, Jennifer L JL Goldman

Indexed on: 12 Dec '18Published on: 12 Dec '18Published in: Infection control and hospital epidemiology


We retrospectively evaluated the effect of penicillin adverse drug reaction (ADR) labeling on surgical antibiotic prophylaxis. Cefazolin was administered in 86% of penicillin ADR-negative (-) and 28% penicillin ADR-positive (+) cases. Broad-spectrum antibiotic use was more common in ADR(+) cases and was more commonly associated with perioperative adverse drug events.