Validation and interpretation of short form 12 and comparison with dermatology life quality index in atopic dermatitis in adults

Research paper by Jonathan I. Silverberg, Joel M. Gelfand, David J. Margolis, Mark Boguniewicz, Luz Fonacier, Mitchell H. Grayson, Peck Y. Ong, Zelma C. Chiesa Fuxench, Eric L. Simpson

Indexed on: 20 Apr '19Published on: 19 Apr '19Published in: Journal of Investigative Dermatology


Quality of life (QOL) assessments are not standardized in atopic dermatitis (AD). We sought to determine the validity of Short-Form 12 (SF-12), a generic QOL assessment, in AD and compare its measurement properties with Dermatology Life Quality Index (DLQI). A cross-sectional, population-based study of 3495 adults was performed, including 602 that met a modified UK Working Party Criteria for AD. SF-12 mental component score (MCS) and SF-6D had a strong correlation with each other, and moderate inverse correlations with Patient-Oriented Eczema Measure, Patient Oriented-Scoring AD (PO-SCORAD), PO-SCORAD–itch, PO-SCORAD-sleep, and numerical rating scale of pain (Pearson correlations, P