Use of dexmedetomidine for pain control.

Research paper by Irina I Grosu, Patricia P Lavand'homme

Indexed on: 02 Feb '11Published on: 02 Feb '11Published in: F1000 medicine reports


For many years, clonidine, an α2-adrenergic receptor (α2-AR) agonist, has been widely used as an analgesic adjuvant in perioperative conditions and pain therapy. Dexmedetomidine (DMET) is currently the most potent α2-AR agonist available and was first approved as a sedative agent for use in the intensive care unit. However, DMET has recently been investigated for its analgesic effects and has the potential to become an alternative to clonidine.