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Uptake during an oral cholera vaccine pilot demonstration program, Odisha, India.

Research paper by Shantanu K SK Kar, Alfred A Pach, Binod B Sah, Anna S AS Kerketta, Bikash B Patnaik, VijayaLaxmi V Mogasale, Yang Hee YH Kim, Shyam Bandhu SB Rath, Sunheang S Shin, Hemant K HK Khuntia, Anuj A Bhattachan, Mahesh K MK Puri, Thomas F TF Wierzba, Linda M LM Kaljee

Indexed on: 09 Dec '14Published on: 09 Dec '14Published in: Human vaccines & immunotherapeutics



Abstract

Approximately 30% of reported global cholera cases occur in India. In 2011, a household survey was conducted 4 months after an oral cholera vaccine pilot demonstration project in Odisha India to assess factors associated with vaccine up-take and exposure to a communication and social mobilization campaign. Nine villages were purposefully selected based on socio-demographics and demonstration participation rates. Households were stratified by level of participation and randomly selected. Bivariate and ordered logistic regression analyses were conducted. 517/600 (86%) selected households were surveyed. At the household level, participant compared to non-participant households were more likely to use the local primary health centers for general healthcare (P < 0.001). Similarly, at the village level, higher participation was associated with use of the primary health centers (P < 0.001) and private clinics (p = 0.032). Also at the village level, lower participation was associated with greater perceived availability of effective treatment for cholera (p = 0.013) and higher participation was associated with respondents reporting spouse as the sole decision-maker for household participation in the study. In terms of pre-vaccination communication, at the household level verbal communication was reported to be more useful than written communication. However written communication was perceived to be more useful by respondents in low-participating villages compared to average-participating villages (p = 0.007) These data on participation in an oral cholera vaccine demonstration program are important in light of the World Health Organization's (WHO) recommendations for pre-emptive use of cholera vaccine among vulnerable populations in endemic settings. Continued research is needed to further delineate barriers to vaccine up-take within and across targeted communities in low- and middle-income countries.