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Up-regulation of the claudin-6 gene in adipogenesis.

Research paper by Yeon-Hee YH Hong, Daisuke D Hishikawa, Hisae H Miyahara, Yukihiko Y Nishimura, Hiroaki H Tsuzuki, Chizu C Gotoh, Tomoyo T Iga, Yasuki Y Suzuki, Sang-Houn SH Song, Ki-Choon KC Choi, Hong-Gu HG Lee, Shinichi S Sasaki, Sang-Gun SG Roh

Indexed on: 25 Nov '05Published on: 25 Nov '05Published in: Bioscience, biotechnology, and biochemistry



Abstract

To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.