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Untersuchung von Cyclamat auf mutagene Wirkung im Dominant-Letal-Test an der Maus

Research paper by D. Lorke

Indexed on: 01 Jun '73Published on: 01 Jun '73Published in: Humangenetik



Abstract

Twenty male NMRI mice were treated on 5 successive days with 10 g Sodium Cyclamate per kilogram body weight orally. After the last application each male was mated with three untreated females. In order to investigate successive germ cell stages of the males they were mated with three further untreated females each week for 10 weeks. The 600 females in all were killed on the 14th day of gestation. The pre-implantation and the post-implantation deaths were determined by counting the number of corpora lutea, implantations, and live and dead embryos. A negative control was carried out using 20 male and 600 female mice. The Sodium Cyclamate treatment neither damaged the males nor reduced the fertility index. No increase in pre-and post-implantation loss was observed. Our investigations gave no indication of any mutagenic effect of Sodium Cyclamate in mice by way of induction of dominant lethal mutations.