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Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striata

Research paper by Aijing Sun, Jieqing Liu, Suqiu Pang, Junsheng Lin, Ruian Xu

Indexed on: 14 Mar '16Published on: 29 Jan '16Published in: Bioorganic & Medicinal Chemistry Letters



Abstract

7-hydroxy-2-methoxy-phenanthrene-3,4-dione and 3’,7’,7-trihydroxy-2,2’,4’-trimethoxy-[1,8’-biphenanthrene]-3,4-dione, two novel compounds and four known compounds were isolated from Bletilla striata. The structures of the compounds were established on the basis of extensive spectroscopic analysis. The two compounds exhibited antiproliferative effects using the MTT test; these effects may be due to cell cycle arrest and inducing ROS generation.

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