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Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry.

Research paper by Matthew J MJ Barnes, Richard R Conroy, David J DJ Miller, John S JS Mills, John G JG Montana, Parminder K PK Pooni, Graham A GA Showell, Louise M LM Walsh, Julie B H JB Warneck

Indexed on: 11 Nov '06Published on: 11 Nov '06Published in: Bioorganic & Medicinal Chemistry Letters



Abstract

The synthesis, physicochemical properties and pharmacological profiles of two novel silicon-containing p38 MAP kinase inhibitors are described.